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KMID : 1033620120390040176
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Clinical and Experimental Reproductive Medicine
2012 Volume.39 No. 4 p.176 ~ p.181
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Clinical application of anti-Mullerian hormone as a predictor of controlled ovarian hyperstimulation outcome
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Lee Jae-Eun
Lee Jung-Ryeol
Jee Byung-Chul
Suh Chang-Suk
Kim Ki-Chul
Lee Won-Don
Kim Seok-Hyun
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Abstract
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Objective: In 2009 anti-Mullerian hormone (AMH) assay was approved for clinical use in Korea. This study was performed to determine the reference values of AMH for predicting ovarian response to controlled ovarian hyperstimulation (COH) using the clinical assay data. Methods: One hundred sixty-two women who underwent COH cycles were included in this study. We collected data on age, basal AMH and FSH levels, total dose of gonadotropins, stimulation duration, and numbers of oocytes retrieved and fertilized. Blood samples were obtained on cycle day 3 before gonadotropin administration started. Serum AMH levels were measured at a centralized clinical laboratory center. The correlation between the AMH level and COH outcomes and cut-off values for poor and high response after COH was analyzed. Results: Concentration of AMH was significantly correlated with the number of oocytes retrieved (OPU; r=0.700, p<0.001). The mean±SE serum AMH levels for poor (OPU≤3), normal (4≤OPU≤19), and high (OPU≥20) response were 0.94±0.15 ng/mL, 2.79±0.21 ng/mL, and 6.94±0.90 ng/mL, respectively. The cut-off level, sensitivity and specificity for poor and high response were 1.08 ng/mL, 85.8%, and 78.6%; and 3.57 ng/mL, 94.4%, and 83.3%, respectively. Conclusion: Our data present clinical reference values of the serum AMH level for ovarian response in Korean women. The serum AMH level could be a clinically useful predictor of ovarian response to COH.
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KEYWORD
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Anti-Mullerian hormone, Ovarian response, Outcome predictor, Controlled ovarian hyperstimulation
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